Prostaglandin-lipid formulations

US5262168A · kind A · utility

Assignee

• The Liposome Company, Inc. · US

Inventors

• Robert P. Lenk · Lambertville, US
• Michelle L. Tomsho · Levittown, US
• Robert L. Suddith · Lawrence, US
• Robert J. Klimchak · Flemington, US

Key dates

• Filing date: Jan 16, 1992
• Grant date: Nov 16, 1993
• Expiry date: Jan 16, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2984
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A liposome composition and methods for making same are disclosed, such compositions comprise an arachidonic acid metabolite such as a prostaglandin, preferably prostaglandin E.sub.1, a lipid, and a drying protectant such as a saccharide. The liposomes may be loaded with prostaglandin passively, or using a transmembrane concentration gradient, preferably using a transmembrane pH gradient. Using this transmembrane loading technique, trapping efficiencies of 50% to 100% are achieved, and the release rate of the prostaglandin from the liposomes is reduced. The liposome size is maintained after lyophilization and reconstitution.