Method for the enzymatic neutralization of heparin
US5262325A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 4, 1991 |
| Grant date | Nov 16, 1993 |
| Priority date | — |
| Expiry date | Apr 4, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/85
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A heparinase formulation derived from Flavobacterium heparinum which meets all requirements for a clinical reagent that can eliminate heparin interference of normal blood function has been developed. The heparinase, derived from Flavobacterium heparinum, is free of a component that inhibits coagulation. It is stable under normal manufacturing, shipping and clinical storage conditions for at least one year. The heparinase in useful in vitro to eliminate the interference in hematological assays due to the presence of heparin. The heparinase is also useful for the in vivo neutralization of heparin during surgical procedures. Advantages of this preparation are that it achieves neutralization faster and more completely than previously available compositions and is stable for long periods of time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.