Aminopyridine compounds

US5262415A · kind A · utility

Assignee

• Green Cross Corporation · JP

Inventors

• Tadahiro Takemoto · Tokyo, JP
• Masahiro Eda · Osaka, JP
• Mitsuyoshi Hihara · Osaka, JP
• Takehiro Okada · Fujisawa, JP
• Hiroshi Sakashita · Komagane, JP
• Miyuki Eiraku · Osaka, JP
• Chikara Fukaya · Osaka, JP
• Norifumi Nakamura · Hirakata, JP
• Masanori Sugiura · Hirakata, JP
• Sumio Matzno · Osaka, JP
• Maki Goda · Osaka, JP
• Yasumi Uchida · Chiba, JP

Key dates

• Filing date: Mar 13, 1992
• Grant date: Nov 16, 1993
• Expiry date: Mar 13, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An aminopyridine compound represented by the formula: ##STR1## wherein n represents 0 or 1; Z represents .dbd.S, .dbd.O, .dbd.NCN or .dbd.CHNO.sub.2 ; R.sub.1 represents --CN, --NR.sub.3 R.sub.4, --CONR.sub.3 R.sub.4, --NHNR.sub.3 R.sub.4, --NHCONHR.sub.3, --NHSO.sub.2 R.sub.3 or --SR.sub.3 ; R.sub.2 represents H, or substituted or unsubstituted alkyl; R.sub.3 and R.sub.4, which may be the same or different, represent H, substituted or unsubstituted alkyl, aryl, substituted or unsubstituted acyl or alkoxycarbonyl group; and R.sub.3 and R.sub.4 may form a heterocyclic ring together with a nitrogen atom to which R.sub.3 and R.sub.4 are bound, through another heteroatom or without it; or an acid salt thereof, which is excellent in pharmacological effect and repressed in side effects as a drug for circulatory diseases.