Antibodies reactive with normal and oncogenic forms of the ras p21 protein
US5262523A · kind A · utility
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6Claims
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Key dates
| Filing date | Nov 27, 1991 |
| Grant date | Nov 16, 1993 |
| Priority date | — |
| Expiry date | Nov 27, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/82
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Antibodies reactive with normal and oncogenic forms of the ras p21 protein. The antibodies are secreted by hybridomas obtained by immunizing mice with the Ha ras p21 protein containing the arginine mutation at position 12 of the protein. The antibodies and immunoreactive fragments thereof of useful for detection, diagnosis, quantitation, staging and classification of normal and activated ras p21s in normal tissues, malignant and premalignant lesions.
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