Method and apparatus for obtaining pure-absorption two-dimensional lineshape data for multidimensional NMR spectroscopy using switched acquisition time gradients
US5262723A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 9, 1991 |
| Grant date | Nov 16, 1993 |
| Priority date | — |
| Expiry date | Jul 9, 2011 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/4608
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A signal function S(t.sub.1, t.sub.2) is obtained from a plurality of coherence transfer pathways in a single acquisition by preparing a molecular system in a coherent non-equilibrium state, and alternately and sequentially detecting signals at individual sampling points, in t.sub.2, from the plurality of coherence transfer pathways by using gradient refocusing of a new pathway after signal detection at a sampling point in another pathway. A frequency domain spectrum S(.omega..sub.1,.omega..sub.2) is constructed by first Fourier transforming the time domain signals S(t.sub.1, t.sub.2) in the t.sub.2 dimension and producing real and imaginary components which modulate as sine and cosine signals in t.sub.1. The real (.omega..sub.2) cosine (t.sub.1) components are combined with the imaginary (.omega..sub.2) sine (t.sub.1) components to form a complex data set S(t.sub.1, .omega..sub.2) that is amplitude modulated in t.sub.1. The complex data set is then Fourier transformed in the t.sub.1 dimension to construct in frequency domain spectrum S(.omega..sub.1, .omega..sub.2) which contains pure absorption lineshapes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.