Biocompatible device with covalently bonded biocompatible agent
US5263992A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 24, 1991 |
| Grant date | Nov 23, 1993 |
| Priority date | — |
| Expiry date | Oct 24, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/925
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The biocompatibility of biomaterials having solid surfaces is improved through coating the same with biocompatible agents. The method for modifying the solid surface to improve biocompatibility employs molecules of a biocompatible agent and a chemical linking moiety possessing a photochemically reactive group capable upon activation of covalently bonding to the solid surface and possessing a different reactive group as capable upon activation of covalently bonding to separate molecules of the biocompatible agent. One of the groups is unresponsive to activation by a stimulus to which the other group is responsive. The method comprises applying stimulus to sequentially activate the groups and covalently bind the different reactive group of the linking moiety to the molecules of the biocompatible agent and to photochemically covalently bind the linking moiety to the solid surface with a sufficient population density to enable the molecules of the biocompatible agent to effectively shield the solid surface and to provide a biocompatible surface.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.