Process for cross-linking of collagen by diphenylphosphorylazide the cross-linked collagen obtained thereby and collagen-based biomaterials thus cross-linked
US5264551A · kind A · utility
9Cited by
2References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 7, 1991 |
| Grant date | Nov 23, 1993 |
| Priority date | — |
| Expiry date | Oct 7, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/40
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The invention relates to a process of cross-linking collagen. This process is of the type comprising the formation of amide bonds by means of acylazide groups and is characterized in that the collagen is reacted with diphenylphosphorylazide. The process according to the invention makes it possible to simplify the collagen cross-linking process and to adjust the degree of cross-linking at discretion without introducing any cross-linking agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.