Process for the preparation of aryl-substituted propionic acid esters
US5264612A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 28, 1992 |
| Grant date | Nov 23, 1993 |
| Priority date | — |
| Expiry date | Sep 28, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C67/347
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a process for the preparation of aryl-substituted propionic acid esters having the formula: ##STR1## wherein R and R.sup.1 are a C.sub.1 -C.sub.12 linear or branched alkyl, a C.sub.5 -C.sub.12 cycloalkyl, a C.sub.6 -C.sub.12 aryl or a C.sub.7 -C.sub.12 alkaryl or aralkyl, R.sup.2 is hydrogen or a C.sub.1 -C.sub.20 linear or branched alkyl and R.sup.3 is a C.sub.1 -C.sub.20 linear or branched alkyl, a C.sub.5 -C.sub.12 cycloalkyl, a C.sub.6 -C.sub.12 aryl or a C.sub.7 -C.sub.20 alkaryl or aralkyl, and may be the same or different, or R.sup.1 is hydrogen, which comprises forming a reaction mixture of a phenol, at least one base catalyst and an acrylate, in the presence of 1,2-dimethoxybenzene, wherein the acrylate is added at once or over a period of time from 5 to 60 minutes at atmospheric pressure. The process results in excellent yields of the desired product with good rates of conversion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.