Method of manufacturing optically active (-)-2-halo-1-(substituted phenyl) ethanol by ketone reduction
US5266485A · kind A · utility
7Cited by
1References
1Claims
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Key dates
| Filing date | Mar 6, 1992 |
| Grant date | Nov 30, 1993 |
| Priority date | — |
| Expiry date | Mar 6, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/942
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method is proposed for manufacturing (-)-2-bromo-1-(3'-chlorophenyl) ethanol by bringing a 2-bromo-1-(3'-chlorophenyl) ethanone into contact with a microorganism belonging to 9 genuses including Ashbya genus and Brettanomycess genus to thereby reduce it asymmetrically into (-)-2-bromo-1-(3'-chlorophenyl) ethanol, and for manufacturing (-)-substituted styrene oxide by cyclizing the obtained alcohol under alkaline conditions. The (-)-substituted styrene oxide can be manufactured efficiently.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.