N-myristoyl transferase inhibitors
US5266576A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 10, 1992 |
| Grant date | Nov 30, 1993 |
| Priority date | — |
| Expiry date | Feb 10, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a compound of formula (I): ##STR1## which can be used as N-myristoyltransferase inhibitors, in which R.sub.1 represents hydrogen, substituted or unsubstituted (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl, (C.sub.3 -C.sub.7) cycloalkyl methyl, substituted or unsubstituted (imidazolyl-2-yl)methyl, substituted or unsubstituted (indol-3-yl)methyl or (1-azaindolizin-2-yl)methyl, PA0 R.sub.2, R.sub.3, which are identical or different, represent hydrogen or (Cl-C6) alkyl, PA1 or when R.sub.1 represents hydrogen, R.sub.2 and R.sub.3 form with the carbon and nitrogen atoms to which they are attached, a mono-, bi- or tricyclic heterocycle, PA0 X represents --CO--, --SO.sub.2 --, --PO(OH)--, PA0 Y represents --COR.sub.5 or --POR.sub.6 R.sub.6 ', PA0 R.sub.4 represents substituted or unsubstituted, linear or branched (C.sub.6 -C.sub.21) alkyl in which, depending on the individual case, one or more methylene may be replaced by oxygen or sulfur or by a p-phenylene ring, their isomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid or base.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.