Inhibitors of nitric oxide synthase and use thereof to prevent glutamate neurotoxicity

US5266594A · kind A · utility

Inventors

• Valina L. Dawson · Baltimore, US
• Ted M. Dawson · Baltimore, US
• Edythe D. London · Baltimore, US
• David S. Bredt · Baltimore, US
• Solomon H. Snyder · Baltimore, US

Key dates

• Filing date: May 12, 1992
• Grant date: Nov 30, 1993
• Expiry date: May 12, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/195
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors of nitric acid synthase can be used to prevent neurotoxicity mediated through glutamate receptors. Nitric oxide synthase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease and Huntington's disease.