(Exo,exo)-7-oxabicyclo[2.2.1]heptane-2,3-dimethanol; monoacyl ester and diacyl ester

US5266710A · kind A · utility

Inventors

• Ramesh N. Patel · Bound Brook, US
• Laszlo J. Szarka · East Brunswick Township, US
• John K. Thottathil · Ivanhoe, US
• David Kronenthal · Yardley, US

Key dates

• Filing date: Jul 30, 1991
• Grant date: Nov 30, 1993
• Expiry date: Jul 30, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/004
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed herein is a process for preparing a novel monoester of the formula ##STR1## in which the associated novel diester ##STR2## is hydrolyzed in the presence of one or more water-soluble enzymes or microorganisms capable of selectively hydrolyzing the --O--C(O)--R.sup.1 group, wherein the treatment is carried out in a biphasic solvent system comprising an aqueous phase having the enzymes or microorganisms and an organic phase immiscible in water having the diester. Also disclosed is a process for preparing [1S-[1.alpha., 2.alpha.(Z),3.alpha.,4.alpha.]]-7-[3[[[[(1-oxoheptyl)amino]acetyl]amino]me thyl-7-oxabicyclo-[2.2.1]hept-2-yl]-5-heptenoic acid using this enzymatic/microbial process.