Aryl alkenoic acid derivatives as leukotriene antagonists
US5266713A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 12, 1992 |
| Grant date | Nov 30, 1993 |
| Priority date | — |
| Expiry date | Aug 12, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/62
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The derivatives have a general formula I ##STR1## in which X is --S--, PA1 W is CH.dbd.CH; PA1 o is 1 to 4; PA1 n is 2 to 6; PA1 m is 0 to 2; PA1 T and Z, same or different, represent oxygen or a direct bond; PA1 R.sup.2 and R.sup.3, represent hydrogen, or fluorine; PA1 A represents carboxyl, CO.sub.2 R.sub.4.sup.4, wherein R.sup.4 is lower alkyl PA1 R is ##STR2## wherein Y represents carboxyl, CO.sub.2 R.sup.4, wherein R.sup.4 is lower alkyl PA2 R.sup.7 and R.sup.8, same or different, represent H or lower alkyl; PA2 R.sup.9 represents --OH, --O-alkyl, NH.sub.2 or a NHCH.sub.2 CO.sub.2 H group; and PA2 R.sup.10 R3 is H.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.