Increasing blood-brain barrier permeability with permeabilizer peptides
US5268164A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 23, 1991 |
| Grant date | Dec 7, 1993 |
| Priority date | — |
| Expiry date | Apr 23, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K7/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated permeabilizers are more efficacious than bradykinin in causing the blood-brain barrier to become more permeable. The permeabilizer A-7 or conformational analogues can be intravenously co-administered to a host together with molecules whose desired destination is the cerebrospinal fluid compartment of the brain. The permeabilizer A-7 or conformational analogues allow these molecules to penetrate the blood-brain barrier and arrive at this destination.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.