Microbial transformation product of L-679,934
US5268370A · kind A · utility
1Cited by
4References
4Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 22, 1992 |
| Grant date | Dec 7, 1993 |
| Priority date | — |
| Expiry date | Apr 22, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/445
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Described is a new immunosuppressant, L-683,519, a monodemethylated rearranged derivative of L-679,934, (FK-506) produced under fermentation conditions utilizing the microorganism, unidentified Actinomycete (Merck Culture Collection MA 6474) ATCC No. 53828. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.