Tumor necrosis factor receptors on microorganisms
US5270038A · kind A · utility
4Cited by
3References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 23, 1992 |
| Grant date | Dec 14, 1993 |
| Priority date | — |
| Expiry date | Jan 23, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/922
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cytokine receptors for tumor necrosis factor .alpha. which are found on microorganisms may, if bound with exogenous TNF.alpha., enhance the response of natural killer cells activated by the microorganisms, or increase TNF.alpha. production by peripheral blood lymphocytes treated with the microorganisms. Microorganisms with receptor-bound exogenous TNF.alpha. have enhanced cellular invasion ability which may change the immune response thereto. Clinical and pharmaceutical applications of these discoveries including vaccines with increased efficacy are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.