Cells expressing a substantial number of surface high affinity HBGF receptors but relatively few low affinity HBGF binding sites and system for assaying binding to HBGF receptor
US5270197A · kind A · utility
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1References
9Claims
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Key dates
| Filing date | Dec 20, 1990 |
| Grant date | Dec 14, 1993 |
| Priority date | — |
| Expiry date | Dec 20, 2010 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A homogeneous population of cells having on average (1) a number of cell surface low-affinity heparin-binding growth factor (HBGF) sites per cell less than 20% of the number of such binding sites found on wild-type CHO-K1 cells (ATCC Accession No. CCL61), and at least three times the number of cell surface high-affinity HBGF receptors per cell found on such CHO-K1 cells; and an assay system utilizing such cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.