Aryloxy-, arylthio-, heteroaryloxy-, heteroarylthio-alkenylene derivatives of amines and pharmaceutical use
US5272144A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 13, 1991 |
| Grant date | Dec 21, 1993 |
| Priority date | — |
| Expiry date | Jun 13, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula ##STR1## wherein each of A and B is a group of formula (i) to (iii): ##STR2## wherein Y is --O--, --S-- or --NR-- in which R is hydrogen or C.sub.1 -C.sub.6 alkyl; each of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 is independently: PA1 a) hydrogen, halogen, hydroxy, cyano or nitro; PA1 b) C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by halogen, PA1 c) C.sub.1 -C.sub.6 alkoxy or C.sub.1 -C.sub.6 alkylthio; PA1 d) C.sub.1 -C.sub.6 alkyl-sulfonyl; PA1 e) a substituted amine group --NR.sub.7 R.sub.8 ; PA1 f) a --COR.sub.12 group; or PA1 g) two adjacent groups of R.sub.3, R.sub.4, R.sub.5 and R.sub.6, taken together, form a C.sub.1 -C.sub.4 alkylenedioxy group; PA2 each of R.sub.1 and R.sub.2 independently is hydrogen, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 alkenyl or C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by phenyl; or R.sub.1 and R.sub.2 taken together with the nitrogen atom to which they are linked, form a substituted or unsubstituted, saturated heterocyclic ring; and the pharmaceutically acceptable salts thereof; are active on the central nervous nervous system, in particular as antidepressant, …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.