2-alkylidene-aminoguanidines and methods of use therefor
US5272165A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Dec 30, 1992 |
| Grant date | Dec 21, 1993 |
| Priority date | — |
| Expiry date | Dec 30, 2012 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/922
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) which contain 2-alkylidene aminoguanidines and derivatives thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.