C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent
US5273979A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 1, 1991 |
| Grant date | Dec 28, 1993 |
| Priority date | — |
| Expiry date | Aug 1, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/01
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Described is a process for producing a new immunosuppressant, a C-31 desmethyl, C-19/C-22 cyclic hemiketal biotransformation analog (Compound I) of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces, lavendulae ATCC No. 55209. Also disclosed is the C-31 methylated derivative (Compound II) of Compound I produced by enzymatic methylation using 31-O-desmethylimmunomycin O-methyl transferase, (DIMT), a methyl transferase enzyme. The macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.