Salts formed between basic histamine H.sub.2 -receptor antagonists and bismuth complexes
US5273984A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 25, 1989 |
| Grant date | Dec 28, 1993 |
| Priority date | — |
| Expiry date | Oct 25, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to salts formed between basic H.sub.2 -receptor antagonists and a complex of bismuth with a carboxylic acid, and solvates of such salts, excluding salts in which the basic H.sub.2 -receptor antagonist is ranitidine. Examples of suitable carboxylic acids are citric acid and tartaric acid. Examples of basic H.sub.2 -receptor antagonists are cimetidine, sufotidine famotidine and nizatidine. The salts are useful in the treatment of gastrointestinal disorders, particularly gastroduodenal conditions. The salts show the antisecretory activity associated with the basic H.sub.2 -receptor antagonist together with antibacterial activity against Campylobacter pylori, and they also possess cytoprotective properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.