Imidazole-containing compositions and methods of use thereof analogs of distamycin
US5273991A · kind A · utility
8Cited by
2References
44Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jul 29, 1992 |
| Grant date | Dec 28, 1993 |
| Priority date | — |
| Expiry date | Jul 29, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/90
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to oligopeptide derivatives that are conjugated to DNA alkylating agents, having the formula ##STR1## wherein m is 0 to 4; n is 2 to 4; each R.sub.1 is the same or different and is hydrogen or C.sub.1 -C.sub.4 alkyl; and R is a DNA alkylating moiety. The present invention is further directed to pharmaceutical compositions thereof, and method for treatment of cancer using the subject compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.