Polymeriable optically active (meth) acrylic acid derivatives

US5274167A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Walter Lange · Cologne, DE
• Bruno Bomer · Bensberg, DE
• Rolf Grosser · Schwandorf, DE
• Dieter Arlt · Cologne, DE

Key dates

• Filing date: Feb 13, 1992
• Grant date: Dec 28, 1993
• Expiry date: Feb 13, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/42
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

An optically active N-(meth)acryloyl amino acid amide of the formula ##STR1## in which R is hydrogen or methyl, PA0 R.sub.1 represents an optionally substituted alkyl, cycloalkyl, aralkyl, aryl or heteroaryl radical, PA0 R.sub.3 represents hydrogen or denotes together with R.sub.1 a tri- or tetramethylene group; PA0 X denotes oxygen or a NR.sub.4 -group wherein R.sub.4 represents hydrogen or alkyl or denotes together with R.sub.2 and the nitrogen atom a 5- to 7-membered ring which ring is optionally substituted by the group COO-alkyl (1-6 carbon atoms) or by one or two alkyl radicals (1-4 carbon atoms) and PA0 R.sub.2 denotes a strongly space-filling hydrocarbon radical. The amide is polymerized and optionally bound to a support such as silica, and can then be used for the chromatographic separation of racemic mixtures of pharmacologically active compounds.