Process for the preparation of a renin inhibiting compound

US5275950A · kind A · utility

Assignee

• Abbott Laboratories · US

Inventors

• Daniel A. Dickman · Grayslake, US
• Bruce W. Horrom · Waukegan, US
• Chi-Nung Hsiao · Libertyville, US
• M. Robert Leanna · Grayslake, US
• Hormoz Mazdiyasni · Marlborough, US
• Howard E. Morton · Gurnee, US
• Thomas M. Zydowsky · Cambridge, US
• William R. Baker · Bellevue, US
• Stephen Condon · Kenosha, US

Key dates

• Filing date: Feb 10, 1993
• Grant date: Jan 4, 1994
• Expiry date: Feb 10, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sulfonyl group, R.sub.6 is hydrogen, alkoxy, halogen or loweralkyl, R.sub.7 is loweralkyl having 2 to 7 carbon atoms, and R.sub.8 is loweralkyl, cycloalkyl, or aryl or a pharmaceutically acceptable acid addition salt thereof.