Phosphorus-containing HMG-COA reductase inhibitors, new intermediates and method
US5276021A · kind A · utility
14Cited by
2References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 19, 1991 |
| Grant date | Jan 4, 1994 |
| Priority date | — |
| Expiry date | Dec 19, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6506
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## wherein R is OH, or salts thereof or lower alkoxy; PA0 R.sup.x is H or alkyl; PA0 X is --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, --CH.sub.2 CH.sub.2 CH.sub.2 -- or --CH.sub.2 O-- (where O is linked to Z); PA0 Z is a hydrophobic anchor, such as ##STR2## wherein the dotted lines represent optional double bonds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.