Thiadiazinones

US5276027A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rochus Jonas · Darmstadt, DE
• Michael Klockow · Lutherstadt Eisleben, DE
• Joachim Leibrock · Gauting, DE
• Hans-Jochen Schliep · Traisa, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE
• Michael Wolf · Darmstadt, DE

Key dates

• Filing date: Oct 22, 1992
• Grant date: Jan 4, 1994
• Expiry date: Oct 22, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## in which R.sup.1 and R.sup.2 are each independently of one another H or A, PA0 R.sup.3 is H, OA or O--C.sub.m H.sub.2m+1-n X.sub.n, PA0 R.sup.4 is --O--C.sub.m H.sub.2m+1-n X.sub.n, PA0 X is F or Cl, PA0 A is alkyl having 1-6 C atoms, PA0 m is 1, 2, 3, 4, 5 or 6 and PA0 n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13, and their salts have positive ionitropic activity and vasodilating action, and promote circulation. In addition, the compounds can be employed for the treatment of asthmatic disease and memory disorders, and have anti-depressive and anti-inflammatory properties.