Heterocyclic 5-lipoxygenase inhibitors
US5276037A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Apr 14, 1993 |
| Grant date | Jan 4, 1994 |
| Priority date | — |
| Expiry date | Apr 14, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns an aryl derivative of the formula I, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl, naphthyl or a heterocyclic moiety, and X.sup.1 is oxy, thio, sulphinyl, sulphonyl, difluoromethylene, imino, (1-4C)alkylimino or optionally substituted (1-4C)alkylene, or X.sup.1 is a group of the formula EQU --X.sup.4 --CR.sub.2 -- or --CR.sub.2 --X.sup.4 -- wherein PA1 X.sup.4 is oxy, thio, sulphinyl, sulphonyl or carbonyl and each R is hydrogen, methyl or ethyl; PA1 each of Ar.sup.2 and Ar.sup.3 is optionally substituted phenylene; PA1 X.sup.2 is oxy, thio, sulphinyl or sulphonyl; PA1 R.sup.1 is (1-4C)alkyl; and PA1 R.sup.2 and R.sup.3 together form a group of the formula --A.sup.1 --X.sup.3 --A.sup.2 -- which together with the carbon atom to which A.sup.1 and A.sup.2 are attached define a ring having 5 to 7 ring atoms, wherein each of A.sup.1 and A.sup.2 is (1-3C)alkylene and X.sup.3 is oxy, thio, sulphinyl or sulphonyl; PA1 which compounds are inhibitors of 5-lipoxygenase and are useful in the treatment of inflammatory or allergic disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.