Analgesic peptides with a trifluoronorvaline modification
US5276137A · kind A · utility
4Cited by
4References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 18, 1990 |
| Grant date | Jan 4, 1994 |
| Priority date | — |
| Expiry date | Dec 18, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to analgesic enkephalin derivatives represented by the following formula: EQU Tyr-A.sub.1 -A.sub.2 -A.sub.3 -A.sub.4 SEQ ID NO:5 (1) and the acid salts thereof, wherein Tyr is L-tyrosine, A.sub.1 or A.sub.2 is a glycine, and that which is not a glycine is an optically active trifluoro amino acid of the formula: ##STR1## wherein n is an integer from 1-3 and m is 1 or 2; A.sub.3 is L-Phenylalanine, or N-methyl-(L)-phenylalanine, and A.sub.4 is L-Methionine, L-Met-OH, L-Met-ol or L-Met-NH.sub.2.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.