Compounds and complexes useful in medical imaging

US5276147A · kind A · utility

Assignee

• Medgenix Group S.A. · BE

Inventors

• John Thornback · London, GB
• Marcel Deblaton · Meux, BE
• Gillian Morgan · Brussels, BE

Key dates

• Filing date: Apr 19, 1990
• Grant date: Jan 4, 1994
• Expiry date: Apr 19, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The subject of the present invention is compounds which correspond to the following general formula: ##STR1## in which R.sub.1 and R.sub.3 independently of one another represent H, an alkyl, alkenyl, cycloalkyl, aryl, arylalkyl or an alkylaryl group, a heterocycle, or groups which are unsubstituted or substituted, in particular by one or more hydroxyl or alkoxy groups or halogen; PA0 n represents an integer from 1 to 5; PA0 i in each case takes values from 1 to n for the n successive ##STR2## links; R.sub.2, R.sub.4.sup.i and R.sub.5.sup.i independently of one another represent H, an alkyl, alkenyl, aryl, alkoxy, hydroxyalkyl, alkoxyalkyl, amido, acyl or carboxyalkyl group, or a salt, or an alkyl ester of the latter; or R.sub.4.sup.i and R.sub.5.sup.i together form an oxo group ##STR3## R.sub.6 and R.sub.7 represent H, or R.sub.6 and R.sub.7 together form an oxo group ##STR4## x represents a 5- or 6-membered heterocycle which contains at least one nitrogen atom, or, in the event that ##STR5## where R.sub.8 and R.sub.9 independently represent H, alkyl, aryl or arylalkyl, and R.sub.10 represents H, alkyl, aryl or arylalkyl. The present invention likewise relates to coordination compl…