Treatment of aluimmunization and refractoriness to platelet transfusion by protein A column therapy
US5277701A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 15, 1991 |
| Grant date | Jan 11, 1994 |
| Priority date | — |
| Expiry date | Nov 15, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2202/0417
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The invention provides a therapeutic method for treating refractoriness to platelet transfusion by isolating blood serum from an alloimmunized patient undergoing platelet transfusion therapy, passing the serum through a bed comprising staphococcal protein A coupled to a solid support and returning the treated plasma to the patient. The method can be conducted by batch-type procedure or by continuously conducting the steps so that blood is withdrawn, passed through the bed, and returned to the patient as a continuous stream. The method is useful to treat alloimmunized patients suffering from leukemia, aplastic anemia, myelofibrosis, myelodysplastic syndrome, or in a bone marrow transplant patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.