Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids
US5278337A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 14, 1992 |
| Grant date | Jan 11, 1994 |
| Priority date | — |
| Expiry date | Oct 14, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C51/487
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture the of aryl-substituted aliphatic carboxylic acid obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with a base producing a salt that has the following properties: PA1 1) has at least one eutectic point; PA1 2) a composition that is not at the eutectic point; and PA1 3) a eutectic composition that is closer to the racemic composition than is the eutectic composition of said aryl-substituted carboxylic acid. Substantially pure, enantiomeric salt is separated, leaving a mother liquor comprising the solvent and aryl-substituted aliphatic carboxylic acid enriched in the other enantiomer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.