Ester-substituted diaminedithiols and radiolabeled complexes thereof
US5279811A · kind A · utility
41Cited by
14References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 26, 1988 |
| Grant date | Jan 18, 1994 |
| Priority date | — |
| Expiry date | Jan 26, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Radiopharmaceuticals consisting essentially of a lipophilic, charge neutral radionuclide complex of a diaminedithiol ligand having 1-4 ester groups of the formula --A--COOR where A is a straight or branched chain alkylene of 0-10 carbon atoms and R is an alkyl group of 1-10 carbon atoms are useful in radioimaging brain perfusion in primates. Ester-substituted diaminedithiols in sterile, pharmaceutically acceptable form, and kits of the diaminedithiols and sterile, non-pyrogenic reducing agents for reducing preselected radionuclides are also provided. Technetium-99m is a preferred radionuclide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.