Cyclic azaaliphatic compounds with a nitroxy function, processes for the preparation thereof and pharmaceutical compositions containing them

US5280031A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Herbert Simon · Lampertheim, DE
• Helmut Michel · Mannheim, DE
• Michael Schultz · Mannheim, DE
• Wolfgang Bartsch · Viernheim, DE

Key dates

• Filing date: May 14, 1991
• Grant date: Jan 18, 1994
• Expiry date: May 14, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/62
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides anti-angina pharmaceutical compositions containing at least one compound of the formula: ##STR1## wherein n is 1 or 2, R is a hydrogen atom or an H--(C.sub.1 -C.sub.8)-alkylene, hydroxy-(C.sub.1 -C.sub.8)-alkylene, R.sup.1 R.sup.2 N--(C.sub.1 -C.sub.8)-alkylene, R.sup.1 R.sup.2 N--(C.sub.1 -C.sub.8)-alkylene-CO--, R.sup.1 R.sup.2 N--CO--NR.sup.3 --(C.sub.1 -C.sub.8)-alkylene or R.sup.1 R.sup.2 N--CO-- radical, A is a valency bond or an --NR.sup.4 --CO-- or --CO-- NR.sup.4 -- radical, R.sup.4 is a hydrogen atom or a straight-chained or branched, saturated or unsaturated or cyclic alkyl radical containing up to 6 carbon atoms and B is a valency bond or a straight-chained or branched alkylene chain containing up to 8 carbon atoms, in which a --CH.sub.2 -- group can be replaced by a cycloalkylene radical containing 3 to 7 carbon atoms.