4(3,5-bis(1,1-dimethylethyl-4-hydroxyphenyl)-4-oxobutanamide compound useful as an anti-inflammatory agent

US5280045A · kind A · utility

Assignee

• The Procter & Gamble Company · US

Inventors

• Roy Lee Martin Dobson · Hamilton, US
• Kenneth Robert Wehmeyer · Cincinnati, US
• Steven P. Sirko · Lancaster, US
• Benjamin Floyd · Cincinnati, US

Key dates

• Filing date: Oct 1, 1992
• Grant date: Jan 18, 1994
• Expiry date: Oct 1, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C235/78
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The subject invention involves compositions comprising 4-(3,5-bis(1,1-dimethylethyl-4-hydroxyphenyl)-4-oxobutanamide, or 4-(3,5-bis-(1,1-dimethylethyl)-4-hydroxyphenyl)-4-oxobutanoic acid and pharmaceutically-acceptable salts thereof, and a pharmaceutically-acceptable carrier. The subject invention also involves methods for treating diseases characterized by inflammation and/or pain, such as rheumatoid arthritis and osteoarthritis, in humans or lower animals by administration of a safe and effective amount of this compound to the human or lower animal in need of such treatment.