Isolated, large latent complexes of TGF-.beta.2 and TGF-.beta.3, and new binding protein for latent form TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3 LTBP-2
US5280109A · kind A · utility
33Cited by
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3Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 27, 1992 |
| Grant date | Jan 18, 1994 |
| Priority date | — |
| Expiry date | Jan 27, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/495
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to large latent complexes of TGF-.beta.2 and TGF-.beta.3, and methods for Isolating these. The complex consists of a dimerized form of TGF-.beta.2 or TGF-.beta.3, the appropriate latency associated peptide, and the latent TGF-.beta.1 binding protein, referred to as LTBP. Also described is a protein which binds to all of TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3, but is immunologically distinct from LTBP, referred to as LTBP-2.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.