LPS-containing analgesics and veterinary analgesics
US5281583A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Aug 22, 1991 |
| Grant date | Jan 25, 1994 |
| Priority date | — |
| Expiry date | Aug 22, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/425
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An analgesic composition comprising an effective amount of at least one member of LPS whose macrophage activation ED.sub.50 is 0.4-100 ng/ml of culture solution in terms of its limulus test-positive LPS content observed on a sigmoid curve prepared by determining the ability of the LPS to activate the TNF productivity of macrophage cultured in vitro, and plotting the macrophage activation ability (%) along the axis of ordinate wherein the ability is estimated to be 0% in the case where it corresponds to the quantity of TNF produced by macrophage with no LPS added thereto, and 100% is assigned to the macrophage activation ability which provides the maximal and constant quantity of TNF produced by the macrophage and plotting the limulus test-positive LPS content of the LPS along the axis of abscissa on a logarithmic scale, in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, high cholesterol level of said animal is prevented or cured; and a method of treating pain of an animal comprising administration to said animal an amount of the above composition effective to prevent or cure the pain of said animal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.