Preparation of an activated polymer ester for protein conjugation
US5281698A · kind A · utility
270Cited by
3References
20Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jul 23, 1991 |
| Grant date | Jan 25, 1994 |
| Priority date | — |
| Expiry date | Jul 23, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/555
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is a process for preparing an activated ester of polyethylene glycol or a polyoxyethylated polyol. After the activated ester is prepared, it can be reacted with a protein to form a polymer/protein conjugate. Conjugation with a polymer can reduce the protein's immunogenicity, increase its solubility, and increase its circulating in vivo half-life. Preferred proteins are IL-2, CSFs, and interferons.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.