Process for the preparation of 3'-aminopropyl 2-sulfatoethyl sulfone

US5281740A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Michael Meier · Frankfurt am Main, DE
• Heinrich Angenendt · Frankfurt am Main, DE

Key dates

• Filing date: Sep 4, 1992
• Grant date: Jan 25, 1994
• Expiry date: Sep 4, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C317/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

In a method for preparing 3'aminopropyl-2-sulphatoethylsulphone in a one-pot process, allyl amine is reacted with mercaptoethanol in dilute sulphuric acid at temperatures of approximately 50.degree. C. up to the boiling point in the presence of a radical starter. The resultant reaction mixture is oxidized with hydrogen peroxide, in the presence of catalytic quantities of a compound of a transition metal of the periodic system of the elements as an oxidation catalyst, at temperatures of approximately 70 to 100.degree.C. and evaporated to dryness after addition of sufficient sulphuric acid to bring the total sulphuric acid content of the mixture to at least 1 mol, referred to the quantity of allyl amine used.