Stabilization of sterilized surfaces for research and medical use
US5283034A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 26, 1992 |
| Grant date | Feb 1, 1994 |
| Priority date | — |
| Expiry date | Mar 26, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16051
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method and composition which permits sterilization of surfaces coupled with biologically active moieties by ionizing radiation is described. The protecting composition contains a surface-stabilizing agent which adheres to the surface and has a molecular weight.gtoreq.5 kd, and an oxygen radical scavenger which is preferably a di- or polysaccharide or reduced form thereof. In the method of the invention, a surface which is coupled to a biologically active agent is protected with the invention composition, dried to a moisture content of less than 1%, and then sterilized by ionizing radiation under standard conditions. The sterilized surfaces of the invention are particularly useful in the production of medical devices intended for extracorporeal use, particularly in cell-separation techniques.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.