Preparation of a compressed membrane containing immobilized biologically acting material
US5283186A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 31, 1991 |
| Grant date | Feb 1, 1994 |
| Priority date | — |
| Expiry date | Dec 31, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/817
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A porous carrier containing an immobilized biologically active material is prepared in which a relatively large amount of an enzyme or an antibody has been immobilized in a manner that produces a low diffusion resistance toward reagents and products. The porous carrier is produced by fixing enzymes or antibodies within internal micropores of the carrier and mechanically compressing the carrier to a final thickness which is in the range of about 0.20 to 0.80 times the uncompressed carrier thickness. The compressed carrier may have a density about 1.25 to about 5.0 times the density of the carrier before compressing. Surprisingly, the compressed carrier exhibits less diffusion resistance to specific reagents and products than would an uncompressed carrier. A preferred porous carrier is a semi-permeable membrane made from synthetic polymers, such as polyvinylidine difluoride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.