Thiazolyl-substituted quinolylmethoxyphenylacetic acid derivatives

US5283252A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Siegfried Raddatz · Hanerau-Hademarschen, DE
• Klaus-Helmut Mohrs · Wuppertal, DE
• Michael Matzke · Wuppertal, DE
• Romanis Fruchtmann · Cologne, DE
• Armin Hatzelmann · Konstanz, DE
• Reiner Muller-Peddinghaus · Bensberg, DE

Key dates

• Filing date: Nov 23, 1992
• Grant date: Feb 1, 1994
• Expiry date: Nov 23, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Thiazolyl-substituted quinolylmethoxyphenylacetic acid derivatives are prepared by reaction of halogenoacetoacetic acid esters with quinolylmethoxyphenylacetic acid thioamides, which are obtainable from corresponding amides with Lawesson's reagent. The substances can be employed in medicaments as inhibitors of enzymatic reactions in the context of arachidonic acid metabolism.