Process for the preparation of 2-chloropyridines

US5283338A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Gunther Cramm · Leverkusen, DE
• Hans Lindel · Leverkusen, DE
• Guido Steffan · Odenthal, DE

Key dates

• Filing date: Apr 1, 1992
• Grant date: Feb 1, 1994
• Expiry date: Apr 1, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/61
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

2-Chloropyridine derivatives of the formula (I) ##STR1## in which R represents hydrogen, C.sub.1 -C.sub.4 -alkyl or halogen and PA1 n represents 0 to 4, are obtained in good yields and high purity when a 2-aminopyridine derivative of the formula (II) ##STR2## in which R and n have the above definitions, is reacted with nitrosyl chloride in a hydrogen chloride-saturated aqueous solution at temperatures between -10.degree. C. and +50.degree. C. with simultaneous introduction of hydrogen chloride.