Diamine oxidase and assay for rupture of amniotic membrane in pregnant mammals
US5284749A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 31, 1990 |
| Grant date | Feb 8, 1994 |
| Priority date | — |
| Expiry date | Oct 31, 2010 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/573
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Assay for detection of a form of diamine oxidase which is present only in amniotic fluid and, more especially, for detection of amniotic membrane rupture by detection of the amniotic fluid diamine oxidase. The assay includes the steps of detecting the amniotic fluid diamine oxidase and distinguishing that from another form of diamine oxidase found in serum. The assay may be carried out on a sample of vaginal fluid from a pregnant female wherein the sample is subjected to the assay to detect the leakage or presence of amniotic fluid diamine oxidase. Purified forms of amniotic fluid diamine oxidase and serum diamine oxidase which is different from amniotic fluid diamine oxidase and found in serum are also described, together with a method of purifying both forms of diamine oxidase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.