Peptide compound and its preparation
US5284828A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 7, 1991 |
| Grant date | Feb 8, 1994 |
| Priority date | — |
| Expiry date | May 7, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel peptides of the formula (I") ##STR1## in which R.sup.1 is hydrogen or acyl, PA1 R.sup.2.sub.c is lower alkyl, PA1 R.sup.3.sub.c is optionally N-substituted indolylmethyl, PA1 R.sup.4 is hydrogen, lower alkyl, C.sub.6-10 ar(lower)alkyl, amino(lower)alkyl, protected amino (lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl or optionally substituted heterocyclic (lower)alkyl, PA1 R.sup.5 is carboxy, protected carboxy, carboxy(lower)alkyl or protected carboxy(lower)alkyl, PA1 R.sup.7 is hydrogen or lower alkyl, and PA1 A is --O--, --NH--, lower alkylamino or lower alkylene, or a pharmaceutically acceptable salt thereof are disclosed. Additionally, the preparation of such peptides is described. The peptides are used to treat endothelin mediated diseases such as hypertension.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.