Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
US5284838A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 18, 1993 |
| Grant date | Feb 8, 1994 |
| Priority date | — |
| Expiry date | Feb 18, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65586
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to 2,2-dimethylchroman-3-ol derivatives of the formula: ##STR1## in which: A, between N and CO, represents the group --CH.dbd.CH--E.dbd.CH-- or the group ##STR2## Z represents a halogen or a cyano, acetyl, trifluoroacetyl, nitro, alkylthio, carboxyl, phosphono, dial-koxyphosphoryl or alkoxycarbonyl group, the alkylthio and alkoxy groups containing from 1 to 3 carbon atoms; PA0 E represents a nitrogen atom or a group C(R.sub.4); PA0 R.sub.1 represents hydrogen, a methyl group or a hydroxyl group and R.sub.2 and R.sub.3 each independently represent hydrogen or a methyl group, it being possible for only one of the substituents R.sub.1, R.sub.2 and R.sub.3 to be methyl; and PA0 R.sub.4 represents a hydrogen atom, a halogen atom, a methyl group or a hydroxyl group; and to the pharmaceutically acceptable salts of the phosphono or carboxyl group. These derivatives have an antiarrhythmic, antiasthma and antihypertensive activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.