Benzo-fused lactams promote release of growth hormone

US5284841A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Lin Chu · Scotch Plains, US
• Michael H. Fisher · Bound Brook, US
• Helmut Mrozik · Matawan, US
• William R. Schoen · Edison, US

Key dates

• Filing date: Feb 4, 1993
• Grant date: Feb 8, 1994
• Expiry date: Feb 4, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are disclosed certain novel compounds identified as benzo-fused lactams ##STR1## which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. The compounds are prepared by substitution of an amino-lactam with a substituted amide function. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.