Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof

US5284872A · kind A · utility

Assignee

• Schwarz Pharma Ltd. · DE

Inventors

• Klaus Sandrock · Langenfeld, DE
• Eike Noack · Neuss, DE
• Edgar Fritschi · Giengen an der Brenz, DE
• Ralf Kanzler · Leverkusen, DE
• Martin Feelisch · Shreveport, US

Key dates

• Filing date: Apr 5, 1991
• Grant date: Feb 8, 1994
• Expiry date: Apr 5, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C323/59
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New organic nitrate compounds, formed by condensing a nitrato alkanoic acid with a sulfur-containing amino acid or peptide followed by the reaction of the resulting product with an amino acid, N-acylamino acid, peptide or an N-acyl peptide to produce a thio ester thereof, which prevent nitrate tolerance or overcome existing tolerance and which are useful for the treatment of cardiac diseases including circulatory diseases, coronary dilation, high blood pressure, cardiac insufficiency and for dilating the peripheral vessels.