Intercellular adhesion molecules, and their binding ligands
US5284931A · kind A · utility
65Cited by
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11Claims
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Key dates
| Filing date | Apr 27, 1990 |
| Grant date | Feb 8, 1994 |
| Priority date | — |
| Expiry date | Apr 27, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/868
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical compositions comprising antibodies to intercellular adhesion molecule-1 (ICAM-1 or CD54) are useful in methods of decreasing the severity of inflammation associated with the adhesion of leukocytes to cells bearing ICAM-1. Treatment with anti-ICAM-1 antibodies reduced the severity of inflammation associated with acute organ or tissue rejection and prolonged allograft survival time. Such compositions may optionally contain other immunsuppressive agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.