Biologically active drug polymer derivatives and method for preparing same

US5286637A · kind A · utility

Assignee

• Debiopharma S.A. · CH

Inventors

• Francesco Maria Veronese · Padova, IT
• Luciana Sartore · Thiene, IT
• Piero Orsolini · Martigny, CH
• Romano Deghenghi · Lausanne, CH

Key dates

• Filing date: Jan 7, 1993
• Grant date: Feb 15, 1994
• Expiry date: Jan 7, 2013

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/832
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New biologically active drug polymer derivatives, namely peptides or protein derivatives, are useful medicaments and are represented by the generic formula: EQU RO--(CH.sub.2 --CH.sub.2 O).sub.n --(CO)--NH--X--(CO)--NH--Z (I) wherein PA1 R represents a lower alkyl group, PA1 n is an integer comprised between 25 and 250, PA1 X when combined with adjacent NH and CO groups represents an amino acid or a dipeptide or tripeptide residue, and PA1 Z when combined with the adjacent NH group represents a biologically active peptide or protein or NH or NH.sub.2 containing drug residue.