Tetrahydropyridinyldibenzazepine derivatives
US5286722A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 25, 1992 |
| Grant date | Feb 15, 1994 |
| Priority date | — |
| Expiry date | Nov 25, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D513/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to tetrahydropyridinyldibenzazepine derivatives of the formula I ##STR1## wherein R.sub.1 is a substituent selected from the group consisting of hydrogen, halogen, and lower alkyl; PA1 R.sub.2 is selected from hydrogen, and unsubstituted or hydroxy substituted lower alkyl or lower alkenyl; PA1 X is O, S, or CH.sub.2 ; PA1 Y is HC.dbd.CH or S; or a pharmaceutically acceptable salt thereof. These compounds are dopamine antagonists and are therefore useful for the treatment of psychotic disorders such as schizophrenia, schizophreniform disorder, delusional disorder, acute manic states, senile and presenile psychotic states, toxic psychoses, psychoactive-substance induced psychoses, symptoms of severe restlessness, hyperexcitability and anxiety, motor disorders, among which Tourette's disorder and Huntington's chorea, nausea and vomiting, hiccup and dizziness.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.